CBD or cannabidiol is one of the 100 cannabinoids present in the cannabis plant, which is researched a lot. Cannabidiol interacts with CB1 receptors in your body, which triggers an entourage effect on your endocannabinoid system. Many anecdotal reports reveal the therapeutic effects and it is a safe alternative. However, just like any other drug incorrect use can cause unintended side effects.
CBD or cannabidiol is one of the 100 cannabinoids, which is researched a lot. Cannabidiol interacts with CB1 receptors in your body, which triggers an entourage effect on your endocannabinoid system.
CBD oil and prescription medications
As the hemp-based CBD industry is moving fast, there arise queries whether CBD oil interacts with prescribed pharmaceutical medication. Is it safe to ingest CBD oil with common over-the-counter drugs? It is normal for prescription and OTC drugs to mingle or work with other chemicals.
Prescription medicines can interact with things like caffeine, alcohol, grapefruit, etc. therefore if you are planning to use CBD oil capsules, it is vital to be aware of its interaction with prescription drugs.
Cytochrome P-450 and CBD
CBD oil can interact with prescription drugs when used in high dosage. One interaction that CBD possible has with the prescription drug is impeding the enzyme system, cytochrome P-450 [CYP450]. It is an enzyme found in your liver and responsible to metabolize more than 60% of medications. Doctors determine proper medication dosage based on the CYP450 system’s processing time.
At sufficient dosage, CBD deactivates P450 temporarily. It has a notable impact on drug metabolism. The CBD’s effect on the enzyme will depend on how firmly cannabidiol binds to the enzyme’s active site before and post oxidation. Nonetheless, even the method of ingestion and the user’s unique attributes even play a role in the enzyme effects. In small doses, CBD does not affect P450.
Grapefruit and CBD
Grapefruit has furanocoumarins, which binds with enzymes CYP450 and neutralizes it. Due to CBD, excessive drug levels enter the bloodstream. After the enzyme gets inhibited by CBD in the gut and liver, it takes several days for the functions to get back to normal.
Beta-blockers and CBD
Beta-blockers lower blood pressure and anxiety. CBD also does the same. Therefore when both are consumed together a rapid low pressure gets experienced. It makes you feel dizzy, lethargic, and weak.
Antidepressants and CBD
Cannabidiol also hinders the system that metabolizes a high percentage of tricyclic antidepressants, SSRIs, and antipsychotics. So if CBD is used with any of these medications it obstructs the metabolism process.
Blood thinners and CBD
Blood thinners taken with CBD are subject to lengthy activity and increased effect. Medication in the blood increases, which is risky.
Metformin and CBD
Metformin helps to manage diabetes. CBD has anti-inflammatory properties that can help people struggling with diabetes. CBD can offset metformin’s effect of reducing blood sugar levels.
Hydrocodone and CBD
Hydrocone and CBD together can significantly quash our central nervous system.
Other drugs not to use with CBD oil
- Immune modulators
- Calcium channel blockers and more
Medication interaction is serious, so it is wise to consult your doctor!